Relation of Circulating Endothelium-derived Microparticle to Carotid Atherosclerosis

Completed

• Conditions: Atherosclerosis

• Registration Number: NCT00795067
• Lead Sponsor: Kurume University

Brief Summary

The investigators hypothesized that circulating endothelium-derived microparticle (EMP) may be a useful surrogate marker of atherosclerosis and future episode of cerebrovascular events. Peripheral blood is drawn at the time of carotid ultrasound examination. Circulating EMPs are counted using flow-cytometry. The correlation among circulating EMP, ultrasound findings, and atherosclerotic risk factors are determined by multiple stepwise regression analysis. The prevalence of cerebrovascular events is also determined during 3-year follow-up period.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-11
• Study First Submitted: 2008-11-20
• Study First Submitted QC: 2008-11-20
• Study First Posted: 2008-11-21
• Primary Completion: 2010-11
• Study Completion: 2013-11
• Status Verified: 2015-03
• Last Update Submitted: 2015-03-30
• Last Update Posted: 2015-03-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 154

Inclusion Criteria

• Patients who undergo carotid ultrasound examination for screening of atherosclerosis

Exclusion Criteria

• Cerebrovascular events within the last 12 months
• Acute coronary syndrome, coronary and peripheral intervention within the last 6 months
• Uncontrolled heart failure
• Other severe systemic diseases

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The number of circulating EMPs	at the time of carotid ultrasound examination

Secondary Outcome Measures

Name	Time	Method
The occurrence of cerebrovascular and/or cardiovascular events	3 years

Trial Locations

Locations (1)

Kurume University Hospital; 🇯🇵 Kurume, Fukuoka, Japan