Low Molecular Weight Heparin in Pregnancies With Unexplained Stillbirths
- Conditions
- Unexplained Stillbirth
- Interventions
- Other: multivitamins and routine antenatal follow up
- Registration Number
- NCT03601338
- Lead Sponsor
- Hawler Medical University
- Brief Summary
Bemiparin for pregnant women with abnormal umbilical artery Doppler ultrasound
- Detailed Description
152 women with history of unexplained stillbirths were identified , umbilical arty Doppler ultrasound was conducted for them at 20-22 weeks gestation . they were divided into two group , group one are those with abnormal resistant index (= or more than 0.6) thy received Bemiparin 2500 IU subcutaneously daily up to 24 hours before delivery .
Group 2 with normal umbilical artery resistant index received no any interventions just routine antenatal follow up .
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 140
- Second pregnancy after previous unexplained fetal death
- Singleton pregnancy
- No any medical disorders during pregnancy like diabetes or Systemic Lupus Erythematosus
- Normally located placenta
- No congenital fetal anomalies
- Patient accept to participate
- Confirmed thrombophilia
- Twin pregnancies
- Refused to participate
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description control group multivitamins and routine antenatal follow up Normal umbilical arty resistant index group received only multivitamins and routine antenatal follow up Bemiparin group Bemiparin Women with high resistant index of umbilical artery received the intervention Bemiparin Sodium 2,500 IU anti Xa/0.2 ml solution for injection in pre-filled syringe provided for each woman . The injections were received daily since 20 weeks gestation and up to 24 hours before delivery Other Name: Hibor; Laboratories Rovi pharmaceuticals
- Primary Outcome Measures
Name Time Method Stillbirth after 20 weeks gestation to the delivery of fetus Intrauterine fetal death
Early neonatal death First week of life Death of newborn
Low birth weight first hour of life New borne with birth weight less than 5th percentile in kilogram
- Secondary Outcome Measures
Name Time Method major abruptio placenta 20-41 week gestation Antepartum hemorrhage
Pre-eclampsia 20-41 week gestation High blood pressure with protein urea
Preterm labor 20-37 weeks delivery of the fetus before 37 weeks gestation
Trial Locations
- Locations (1)
Hawler Medical University
🇮🇶Erbil, Kurdistan Region, Iraq