Vitamin A and Response to Endotoxin
- Conditions
- TNF-alfaEndotoxin Levels
- Registration Number
- NCT00168649
- Lead Sponsor
- Bandim Health Project
- Brief Summary
Vitamin A given as treatment and pre-treatment has reduced the severity of symptoms after infusion with endotoxin in several animal models. We intend to examine the effect of vitamin A as pre-treatment on the response to endotoxin in humans. We furthermore wish to examine the long-term effects of vitamin A on the response to endotoxin. We hypothesise that vitamin A decreases endotoxin levels and TNF-alfa responses.
- Detailed Description
Vitamin A given as treatment and pre-treatment has reduced the severity of symptoms after infusion with endotoxin in several animal models. We intend to examine the effect of vitamin A as pre-treatment on the response to endotoxin in humans. As studies in children in low-income countries have indicated that vitamin A has long-term effects on the immune system, we furthermore wish to examine the long-term effects of vitamin A on the response to endotoxin. This will be done in an established model using infusion with endotoxin to male human volunteers. We hypothesise that vitamin A decreases endotoxin levels and TNF-alfa responses. Furthermore, we hypothesise that it reduces oxidative stress and injury.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Male
- Target Recruitment
- 40
Healthy, male, between 18 and 35 years of age, non-smoker, no medicine, no infections in preceding 14 days
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method TNF-alfa levels Endotoxin levels
- Secondary Outcome Measures
Name Time Method Haematological values Clinical markers Retinol and beta-caroten levels Measures of oxidative injury and stress
Trial Locations
- Locations (1)
Rigshospitalet, Department M7641
🇩🇰Copenhagen, Denmark