Norwegian Study of Oral Cladribine and Rituximab in Multiple Sclerosis (NOR-MS)

Phase 3

Completed

• Conditions: Multiple Sclerosis; Relapsing Multiple Sclerosis
• Interventions: Biological: Rituximab; Drug: Cladribine

• Registration Number: NCT04121403
• Lead Sponsor: Oslo University Hospital

Brief Summary

The main aim and overall objective of the study is to assess whether rituximab is non-inferior to cladribine for the treatment of relapsing MS. Secondly, the investigators will test specific blood and MRI biomarkers that may contribute to future personalized treatment for MS patients. Furthermore, the investigators want to evaluate the health economic consequences of the two therapies.

Detailed Description

Multiple sclerosis (MS) is a demyelinating and neurodegenerative inflammatory disease of the central nervous system, affecting more than 12 000 patients in Norway and more than 2.2 mill patients worldwide.

Oral cladribine is one of the first choices for highly efficient disease modulatory treatment (DMT), while Rituximab is used off-label as DMT in relapsing MS. Large observational studies indicate good tolerance and treatment effect of rituximab in MS and studies from other diseases indicate a good safety profile. However, no phase 3 studies have been performed to test whether rituximab is as efficient as established MS treatments. Formal safety data is also lacking for the treatment with rituximab in MS.

The investigators will perform a prospective randomized open-label blinded endpoint multicenter non-inferiority study. The primary objective is to test whether rituximab is non-inferior to oral cladribine in the treatment of relapsing MS. 264 MS patients aged 18-65 years with relapsing MS will be recruited from 10 centers and followed for 96 weeks. The primary endpoint is difference in new T2 lesions between the groups. Furthermore, the investigators will test novel blood sample and MRI biomarkers to provide tools for personalized MS treatments. Finally, the health economic consequences of these treatment options will be evaluated.

This study will guide clinicians and patients in the future treatment choice for MS and can potentially make a huge impact on the costs of future MS treatment.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2019-09-23
• Study First Submitted QC: 2019-10-08
• Study First Posted: 2019-10-09
• Study Start: 2019-10-16
• Primary Completion: 2024-08-31
• Study Completion: 2024-08-31
• Status Verified: 2024-12
• Last Update Submitted: 2024-12-11
• Last Update Posted: 2024-12-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 267

Inclusion Criteria

• Age between 18 and 65 years
• A diagnosis of relapsing MS according to the 2017 McDonald criteria
• Disease activity seen as either a clinical relapse or MRI activity during the last 12 months
• EDSS between 0 and 5.5
• Thrombocytes and leukocytes within normal range, and lymphocytes above 0.8 x10 9/L before first dose of study medication
• A) For women of childbearing potential: accepting to use adequate contraception in the trial period. If randomized to cladribine, women who use systemic hormonal contraception must accept to use additional barrier contraception during each treatment cycle and for four weeks after each treatment cycle.
• B) For men: If randomized to cladribine, accepting to use adequate contraception in the safety period of 6 months after each treatment cycle.
• Able to understand written and spoken Norwegian or English
• Able to complete treatment or follow-ups in the study (e.g. no contraindications for MRI, severe psychiatric disease, drug abuse or plans of moving)
• Signed informed consent

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Exclusion Criteria

• Any contraindication or increased risk of side-effects from rituximab or cladribine (such as ongoing acute or chronic infection, live vaccination less than 4 weeks before start of treatment or planned live vaccination, immunocompromised, previous or active malignant disease, ongoing glucocorticoid treatment or allergy against any products of the medication)
• Previous use of any of cladribine, rituximab, alemtuzumab, ocrelizumab, hematopoietic stem cell therapy (HSCT) or other immunosuppression with long lasting effects
• Fingolimod or natalizumab treatment within the last six months before inclusion
• Current pregnancy or lactation

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Rituximab	Rituximab	Biosimilar rituximab concentrate for solution for infusion
Cladribine	Cladribine	Mavenclad oral cladribine tablets

Primary Outcome Measures

Name	Time	Method
Number of new or enlarging cerebral MRI T2 lesions	Week 12-96	The primary outcome is the number of new or enlarging cerebral MRI T2 lesions per patient from week 12 to week 96

Secondary Outcome Measures

Name	Time	Method
T2 lesions after 48 weeks	Week 12-48	Number of new or enlarging cerebral MRI T2 lesions per patient from week 12 to week 48
Annual clinical relapse rate (ARR)	Week -2 to 96	Annual clinical relapse rate (ARR) at 24, 48 and 96 weeks
Relapse-free patients	Week -2 to 96	Proportion of relapse-free patients at 24, 48 and 96 weeks
Change in disability	Week -2 to 96	Change in disability on the Expanded Disability Status Scale (EDSS) from week -2 to 48 and 96 weeks. Disability progression is defined as an increase in EDSS of at least 1.5 points if baseline EDSS was 0, 1 point with baseline EDSS 0.5-4.5 and 0.5 point with baseline EDSS 5-5.5. EDSS is a scale from 0-10 measuring neurological disability.
Disability progression	Week -2 to 96	Proportion of patients with 24 weeks confirmed disability progression (24-CDP) on EDSS at 48 and 96 weeks

Trial Locations

Locations (11)

Department of Neurology - Drammen, Vestre Viken HF; 🇳🇴 Drammen, Buskerud, Norway

Department of Neurology - Lillehammer, SI Lillehammer; 🇳🇴 Lillehammer, Oppland, Norway

Department of Neurology, Stavanger universitetssykehus; 🇳🇴 Stavanger, Rogaland, Norway

Department of Neurology - Førde, Helse Førde HF; 🇳🇴 Førde, Sogn Og Fjordane, Norway

Department of Neurology - Skien, Sykehuset Telemark; 🇳🇴 Skien, Telemark, Norway

Department of Neurology - Tromsø, University Hospital of North Norway; 🇳🇴 Tromsø, Troms, Norway

Department of Neurology - Kristiansand, Sørlandet sykehus HF; 🇳🇴 Kristiansand, Vest-Agder, Norway

Department of Neurology - Tønsberg, Sykehuset i Vestfold HF; 🇳🇴 Tønsberg, Vestfold, Norway

Department of Neurology, Oslo University Hospital; 🇳🇴 Oslo, Norway

St. Olavs Hospital, Trondheim University Hospital; 🇳🇴 Trondheim, Norway

Department of Neurology - Kalnes, Sykehuset Østfold HF; 🇳🇴 Sarpsborg, Østfold, Norway