Antimicrobial Effect of Tropolone Containing Versus Tropolone Free Mouthwash - Randomized Clinical Trail
试验速览
- 阶段
- 早期 1 期
- 状态
- 招募中
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Bacterial count.
研究概览
简要总结
The objective of this study is to compare the effect of Tropolone containing mouthwash versus CHX 0.2% mouthwash in reducing intraoral microorganism. Randomized clinical trial study
详细描述
Dental Caries disease prevented through the antibacterial mouthwash.
The prevalence of dental caries disease continues to be a challenge for oral health care professionals to this day.
In fact an alarming 92% of US adults (aged 20 to 64 years) have a history of dental caries. While strides have been made since the early 1970s the problem persists.
From the mid1990s until 2004 according to the National Health and Nutrition examination survey there was a small but significant increase in primary decay. This trend was even more severe in younger.
Dental Caries disease are not being treated can eventually turn into more serious issues. Fluoride has long been known as one of the key components to good oral health and the prevention of dental caries disease. It is a naturally occurring mineral that makes tooth enamel more resistant to acid producing bacteria that cause dental caries disease while also repairing teeth in the very early microscopic stages. While the use of fluoride in toothpaste has been responsible for a drop in dental caries disease since 1960 this significant problem still persists.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Outcomes Assessor)
盲法说明
A third party will perform the allocation sequence and assign the participants to rinsing agent in sequentially numbered opaque envelop.
入排标准
- 年龄范围
- 18 Years 至 45 Years(Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients should be between 18- 45 years of age.
- •All the volunteers participated in this study will be healthy looking with free medical history.
- •The volunteers will be asked to suspend their usual oral hygiene practice from two to four days before experiment studying.
排除标准
- •Patients with a compromised medical condition.
- •Volunteers that receive any antimicrobial agent during at least two weeks prior to study.
- •Volunteer with fixed, removable prosthesis or orthodontics appliance.
- •Volunteers with DMF above six will be excluded.
研究组 & 干预措施
Listerine total care zero
Listerine total care zero
干预措施: Listerine total care zero (Combination Product)
Chlorhexidine Mouthwash (0.2%).
Chlorhexidine Mouthwash (0.2%).
干预措施: Chlorhexidine Mouthwash (0.2%). (Combination Product)
结局指标
主要结局
Bacterial count.
时间窗: Change from the baseline immediate after using mouthwash, at one week after mouthwash and at two weeks after regular use of mouthwash
viability counts of Mutans Streptococci lactobacilli
次要结局
未报告次要终点
研究者
Mohamed Awad Mohamed Abdelkadir
Master Degree
Cairo University
