An Integrative Clinicopathological Decision Support System for Kidney Transplant Rejection

The following data/features are collected prospectively and structured in the electronic medical records:

Demographics:

• Date of transplantation
• Date of graft failure
• Last date of follow-up
• Time after transplantation of survival (number of days);
• kidney survival;
• recipient death;
• recipient gender;
• recipient age at time of transplantation;
• recipient weight at time of transplantation;
• recipient BMI at time of transplantation;
• recipient race;
• recipient diabetes prior to transplantation;
• the Belgian Index for Multiple Deprivation (BIMD);
• combined vs single transplant (we included only single transplants);
• repeat transplant vs. first transplant;
• diagnosis of the original kidney disease (prior to transplantation);
• donor type (living vs. deceased);
• donor gender;
• donor age in years;
• donor diabetes yes vs no;
• HLA genotype of donors and recipients, number of HLA A mismatches between donor and recipient (0-2); number of HLA B mismatches between donor and recipient (0-2); number of HLA DR mismatches between donor and recipient (0-2); number of total HLA mismatches between donor and recipient (0-6); high-resolution genotyping of donors and recipients HLA genes (11 loci);
• cold ischemia time
• warm ischemia time
• operation time

Graft functional data:

• Serum creatinine values from day of transplantation onwards;
• Proteinuria values from day of transplantation onwards