Exercise and Acarbose in Type 2 Diabetes

Phase 4

Completed

• Conditions: Diabetes Mellitus Type 2
• Interventions: Behavioral: Exercise; Other: Exercise + Acarbose; Drug: Acarbose

• Registration Number: NCT01244971
• Lead Sponsor: Karolinska Institutet

Brief Summary

The purpose of this study is to investigate the impact of exercise training, Acarbose, and the combination of exercise and Acarbose on glycemic control, body composition, insulin sensitivity and other cardiovascular risk markers in type 2 diabetes. Further, muscle biopsies will be obtain to study gene expression. Our hypothesis is that the combination therapy will be superior to monotherapy with exercise or Acarbose.

Detailed Description

Not available

Study Timeline

• Status Verified: 2003-12
• Study Start: 2004-01
• Primary Completion: 2004-06
• Study First Submitted: 2010-11-19
• Study First Submitted QC: 2010-11-19
• Last Update Submitted: 2010-11-19
• Study First Posted: 2010-11-22
• Last Update Posted: 2010-11-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 62

Inclusion Criteria

Men and women, diagnosis of type 2 diabetes established since at least three months, treatment with diet or maximum one oral anti-diabetic drug, GHb < 8.5 %, age 45 - 60 years, BMI 25 - 30 kg/m2, no participation in any regular exercise program.

Exclusion Criteria

Unable to perform exercise, significant GI-disease, severe heart-disease, renal failure

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Exercise	Exercise	-
Exercise + Acarbose	Exercise + Acarbose	-
Acarbose	Acarbose	-

Primary Outcome Measures

Name	Time	Method
Glycemic control	12 weeks	Glycated A1c

Trial Locations

Locations (1)

Enheten för Metabol Kontroll, Endokrinkliniken, Karolinska University Hospital; 🇸🇪 Stockholm, Sweden