Effects of Transcranial Direct Current Stimulation (tDCS) on Associative Learning in Older Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 14
- 试验地点
- 1
- 主要终点
- Performance in a verbal associative learning paradigm under anodal tDCS compared to sham
研究概览
简要总结
The aim of this study is to investigate whether a tDCS-accompanied training of audio-visual associative memory leads to a performance improvement in healthy older individuals.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 50 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age: older in working age (50-65 years)
- •Right handedness
- •unobtrusive neuropsychological screening
排除标准
- •Mild cognitive impairment (MCI) or other neurological diseases.
- •History of severe alcoholism or use of drugs.
- •Severe psychiatric disorders such as depression, psychosis (if not in remission) and severe untreated medical problems.
- •Contraindication for MRI (claustrophobia, metallic implants, ferromagnetic metals in the body, disorders of thermoregulation, pregnant women).
研究组 & 干预措施
Anodal tDCS + training
Combination of intensive training of picture-word associations (Wernicko task) with anodal stimulation
干预措施: tDCS (Device)
Anodal tDCS + training
Combination of intensive training of picture-word associations (Wernicko task) with anodal stimulation
干预措施: training (Behavioral)
Sham tDCS + training
Combination of intensive training of picture-word associations (Wernicko task) with sham stimulation
干预措施: tDCS (Device)
Sham tDCS + training
Combination of intensive training of picture-word associations (Wernicko task) with sham stimulation
干预措施: training (Behavioral)
结局指标
主要结局
Performance in a verbal associative learning paradigm under anodal tDCS compared to sham
时间窗: assessed immediately after training period (several learning blocks) compared to sham
Investigation whether anodal tDCS leads to improved performance accuracy in the Wernicko task compared to sham stimulation.
次要结局
- Functional connectivity predictors(assessed during baseline testing)
- Structural predictors(assessed during baseline testing)
- Other cognitive outcome: Attention(assessed directly before and immediately after tDCS + training compared to)
- Genotyping of learning related polymorphisms(: assessed during baseline screening)
- Other cognitive outcome: Working memory(assessed directly before and immediately after tDCS + training compared to)
研究者
Agnes Flöel
Prof. Dr.
Charite University, Berlin, Germany