Evaluation of the effect of menstrual blood stem cells in recurrent pregnancy loss
- Conditions
- Recurrent pregnancy loss.Pregnancy, childbirth and the puerperium
- Registration Number
- IRCT20210513051280N2
- Lead Sponsor
- Iranian academic center for education culture and research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Female
- Target Recruitment
- 40
Women with primary recurrent pregnancy losses (at least two successive pregnancy losses excluding blighted ovum confirmed by sonography or pathology till 10th week of gestation
Maximum patient age: 37 years, no history of previous live birth
FSH level of less than 10 mIU/mL
Negative test results for HIV, HBS Ag, HCV and VDR
Having previous history of successful pregnancy
Chromosomal abnormalities in parents
Uterine anatomic abnormalities
Hormonal abnormalities
PCO with metabolic syndrome
Uncontrolled diabetes
Stage 3 or 4 endometriosis
Autoimmune diseases including rheumatoid arthritis, thyroid autoimmunity, lupus and anti-phospholipid antibodies
History of cancer, chemotherapy and radiotherapy
Spermogram abnormalities (DFI more than 30 and normal sperm morphology less than 2%
History of immunosuppressive drugs intake including corticosteroids during the past three months
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pregnancy loss. Timepoint: Before 20th week of gestation. Method of measurement: Sonography.
- Secondary Outcome Measures
Name Time Method Clinical pregnancy rate. Timepoint: 6th week of pregnancy. Method of measurement: Sonography.;Live birth rate. Timepoint: At the end of pregnancy period. Method of measurement: Delivery.;Twin pregnancy. Timepoint: 6th week of gestation. Method of measurement: Sonography.;Newborn weight. Timepoint: After delivery. Method of measurement: Weighting.