Comparative Investigation efficacy of cognitive rehabilitation and donepezil on memory, attention, quality of life and depression in patients with multiple sclerosis.

Not Applicable

• Conditions: Multiple Sclerosis.; Demyelinating diseases of the central nervous system; G35-G37

• Registration Number: IRCT2016042227522N1
• Lead Sponsor: Vice Chancellor Of Rsearch, Isfahan University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

definite diagnosis of MS according to the McDonald criteria by neurologist ; ability to participate in the interview and convey information and their experiences ; desire to participate in the study and necessary cooperation and motivation for interview ; absence of chronic disease other than multiple sclerosis ; age between 20 and 60 years ; having at least read and write education ; lack of renal and hepatic diseases ; non-use of anticholinergic drugs ; patients with Expanded Disability Status Scale up to 5/5 on the criteria of John Kurtzke ; patients with mild to moderate level of memory performance ; study of depression of subjects according to Beck for Primary Care questionnaire to verify the inclusion and omission of severe depression.
Exclusion criteria: loss of each conditions during the study inclusion ; lack of desire to continue this research collaboration ; inability to participate in therapy sessions regularly ; relapses of disease during the intervention period that lead to hospitalization in the hospital.

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Memory. Timepoint: Before Intervention & 3 month after Intervention. Method of measurement: Autobiographical Memory Test , The Prospective and Retrospective Memory Questionnaire , The Early Motor Questionnaire.;Attention. Timepoint: Before Intervention & 3 month after Intervention. Method of measurement: Digit Span Test.;Depression. Timepoint: Before Intervention & 3 month after Intervention. Method of measurement: Beck for Primary Care questionnaire.;Quality of Life. Timepoint: Before Intervention & 3 month after Intervention. Method of measurement: Quality of Life 54 questionnaire.