Treatment Effects Inclusive Cognitive Impact and Possibilities to Individually Adjusted Treatment in Patients With Intracranial Tumors With Clinical, Neuropsychological and Imaging Parameters.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 150
- 试验地点
- 2
- 主要终点
- Early prediction of treatment response based on MRI parameters.
研究概览
简要总结
The main purposes with this trial is to investigate the potential of MRI with diffusion and blood volume, flow in brain to diagnose and to measure treatment effects in patients with intracranial tumors, especially gliomas and metastases in a prospective trial, to evaluate the possibilities to individually adjusted treatment in this category of patients depending on treatment outcomes measured by MRI, to perform clinical follow up in connection with MRI to evaluate a correlation and to perform testing of cognitive ability before, during, and after treatment and to investigate if given treatment causes any decrease in the patients habitual state.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18 years or older
- •Suspected primary brain tumor, verified glioblastoma or non surgically treated metastases from solid tumor
- •Increasing MRI changes in patients with previous verified glioblastoma
- •Be able to speak Swedish without difficulties (because of the neuropsychological investigations)
- •Written informed concent
排除标准
- •Unability to perform MRI
结局指标
主要结局
Early prediction of treatment response based on MRI parameters.
时间窗: Three weeks compared to baseline.
次要结局
- Neuropsychological function.(Month 3, 12, and 18 compared to baseline)