TRASOUND-GUIDED SAPHENOUS NERVE BLOCK: A DOSE-FINDING STUDY IN HEALTHY VOLUNTEERS

Phase 4

Completed

• Conditions: postoperative pain; nerve blockade

• Registration Number: NL-OMON42255
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 25

Inclusion Criteria

Age 18-65 years, ASA physical status I-II (healthy).

Exclusion Criteria

allergy against local anesthetics, contraindication for saphenous nerve block (infection at injection site, local pathology), ingestion of any pain medication within the past 24 hours, pregnancy or breastfeeding status.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary objective of the present study is to determine the ED95 of<br /><br>mepivacaine 2% to elicit saphenous nerve blockade, tested dichotomous (yes/no)<br /><br>by loss of sensation to pinprick at all of the following locations:<br /><br>- the skin over the apex of the Patella,<br /><br>- the skin of the medial aspect of the medial facet of the tibial plateau and<br /><br>- the skin over the medial ankle. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary aims are to evaluate the influence of volume on duration of sensory<br /><br>blockade, on the extent of potential motor blockade, block onset and block<br /><br>offset, and maximum spread of sensory block on the skin surface. </p><br>