Volume Controlled Ventilation vs Autoflow-volume Controlled Ventilation

Not Applicable

Withdrawn

• Conditions: Prostate Cancer
• Interventions: Device: volume controlled ventilation; Device: autoflow-volume controlled ventilation

• Registration Number: NCT02512120
• Lead Sponsor: Korea University Anam Hospital

Brief Summary

Volume controlled ventilation(VCV) is a most common used ventilation mode during general anesthesia. But VCV can cause high airway peak pressure when patient under steep Trendelenberg position with pneumoperitoneum. Autoflow-VCV can reduce airway peak pressure and improve dynamic compliance. We will compare parameters(arterial blood gas analysis, airway compliance, etc) when each group applied VCV and autoflow-VCV during RALP.

Detailed Description

Robot assisted laparoscopic radical prostatectomy(RALP) has been used to treatment of prostate cancer since 2001. RALP offers some advantage such as reduced blood loss, sparing nerves, less postoperative pain. However, RALP require steep Trendelenberg position with pneumoperitoneum. It can cause increased airway peak pressure and unwanted hemodynamic effect under conventional volume controlled ventilation(VCV). Autoflow-VCV use decelerating flow, can reduce airway peak pressure and improve dynamic compliance.

We will compare parameters(arterial blood gas analysis, airway compliance, etc) when each group applied VCV and autoflow-VCV during RALP.

Study Timeline

• Study First Submitted: 2015-07-29
• Study First Submitted QC: 2015-07-29
• Study First Posted: 2015-07-30
• Study Start: 2015-08
• Status Verified: 2016-04
• Last Update Submitted: 2016-04-26
• Last Update Posted: 2016-04-27
• Primary Completion: 2016-10
• Study Completion: 2017-12

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: Male
• Target Recruitment: Not specified

Inclusion Criteria

• Adult (age 19-65)
• American Society of Anesthesiology Classification I-III

Exclusion Criteria

• cardiovascular disease, cerebrovascular disease, pulmonary disease
• over BMI 30

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
volume controlled ventilation	volume controlled ventilation	Randomized 23 patients will be applied VCV during RALP.
autoflow-volume controlled ventilation	autoflow-volume controlled ventilation	Randomized 23 patients will be applied autoflow-VCV during RALP.

Primary Outcome Measures

Name	Time	Method
Airway pressure	4hours	Airway pressure will be measured under specified ventilation mode.

Secondary Outcome Measures

Name	Time	Method
Vital sign	4hours	Vital sign will be measured under specified ventilation mode.