Personalized Evidence-based Medicine Improves Outcomes of Antihypertensive Therapy in Patients With Comorbidities
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 100,000
- 试验地点
- 1
- 主要终点
- The percentage of personalized evidence-based medicine recommendations
研究概览
简要总结
A retrospective analysis
详细描述
This retrospective study will be performed using all-Russian nationwide database of anonymized medical health claims and administrative data. The database holds information on diagnoses, patient data, medications, results of examinations, laboratory values, and genomic information, visits, follow up and outcomes. Participating health care organizations include a mix of hospital, primary care, and specialty treatment providers spanning a wide range of geographies, age groups, and income levels.
This study will analyze of outcomes according to comorbidity and antihypertensive drug prescriptions. The study will include patients who were first diagnosed with hypertension, attended the hospital as an outpatient due to hypertension, and received their antihypertensive prescription as an outpatient. To be eligible for inclusion, patients must have had comorbidities and outpatient visits or hospitalizations (for any indication) during the 3-years. The study will focused on comorbidities for choice of antihypertensive drug therapy: diabetes mellitus, dyslipidemia, gout/hyperuricemia, heart diseases, cerebrovascular diseases, and renal diseases.
We going to analyze the EMR of patients who had hypertension and comorbidities by CDSS (MedicBK) utilizing a core laboratory.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients who were first diagnosed with hypertension, attended the hospital as an outpatient due to hypertension, and received their antihypertensive prescription as an outpatient. To be eligible for inclusion, patients had to have comorbidities and outpatient visits or hospitalizations (for any indication) during the 3-years.
排除标准
- 未提供
研究组 & 干预措施
By CDSS (MedicBK) Analysis
干预措施: antihypertensive therapy (Drug)
General practice
干预措施: antihypertensive therapy (Drug)
结局指标
主要结局
The percentage of personalized evidence-based medicine recommendations
时间窗: 3-year
The percentage of personalized EBM recommendations acted on by clinicians for antihypertensive therapy in patients with comorbidities. All discrepancies between routine and CDSS-recommended treatment resulting in frame of guideline-based therapy and personalized EBM therapy will be adjudicated by core laboratory.
次要结局
- Predictors(3-year)
- 3-year FU outcomes(3-year)
- Quantify the performance of the CDSS (MedicBK) algorithm(3-year)
研究者
Evgeny Pokushalov
Director for research and development
Center of Personalized Medicine, Pirogova