Muscle fatigue patterns in CKD population

Not yet recruiting

Conditions: Chronic kidney disease, stage 3 (moderate),

Registration Number: CTRI/2025/03/083449

Lead Sponsor: Vinitha Arasu

Brief Summary: Informed written consent will be obtained from all the potential participants in regional language. Eligible participants will be administered with 13 items self- reported FACIT-F questionnaire (Functional Assessment of Chronic Illness therapy -Fatigue). Participant’s with scores 30 or less in FACIT-F is considered to have a severe fatigue symptoms. Selected participants will be taken for EMG fatigue analysis. Cardiologist and Nephrologist clearance will be taken before exposing them to fatigue protocol in order to ensure the safety of the CKD Patients. Participants will be clearly familiarized with the procedures of EMG before starting the protocol. The surface EMG electrodes and sensors will be placed over bilateral Vastus medialis and Medial head of gastrocnemius based on the SENIAM guidelines. Participants will be asked to perform the paced sit to stand protocol as per guidelines. Procedures of Paced sit to stand Protocol: Participants will be asked to be seated in 45 cm height chair or stool without the armrest. They will be asked to perform stand to sit in a chair repeatedly. The frequency of the sit to stand will be controlled by metronome (30 cycles /minute).The fatigue protocol will be stopped when one of the following conditions are met; When the participant indicate their inability to continue, the movement frequency fall below and remain below 30 cycles/ min after encouragement, or after 30 min.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 384

Inclusion Criteria

Medically diagnosed patients of moderate to severe CKD (Stage 3a -5) Self reported fatigue symptoms using FACIT.
F (Scores 30 or less).

Exclusion Criteria

Severe cognitive impairments Severe neurological diseases, Amputation, Acute kidney disease, Those with orthopedic implant in the lower limb, Uncontrolled hypertension at rest, OA and RA of Lower extremity joints, Skin conditions that may not permit placement of surface electrodes.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
EMG indices of Mean power frequency and median frequency	Baseline

Secondary Outcome Measures

Name	Time	Method
Self reported fatigue questionnaire FACIT-F	Functional Assessment of Chronic Illness Therapy-Fatigue

Trial Locations

Locations (1): SRM Medical College Hospital and Research Centre
🇮🇳
Kancheepuram, TAMIL NADU, India
SRM Medical College Hospital and Research Centre
🇮🇳Kancheepuram, TAMIL NADU, India
DrVinitha Arasu
Principal investigator
8637488187
vinithabks@gmail.com