Comparison of combination of sedatives(Propofol and ketamine vs Propofol and Fentanyl) in patients on ventilator
- Conditions
- Health Condition 1: J952- Acute pulmonary insufficiency following nonthoracic surgeryHealth Condition 2: B968- Other specified bacterial agents as the cause of diseases classified elsewhereHealth Condition 3: I999- Unspecified disorder of circulatory system
- Registration Number
- CTRI/2021/11/038112
- Lead Sponsor
- AIIMS Jodhpur
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
All ICU patients between 18 to 80 years who are expected to be on mechanical ventilation for more than 48 hours
1) Patients weaned of mechanical ventilation within 48 hrs of mechanical ventilation
2) Patients who are on non invasive mode of ventilation
3) Patients who had cardiac arrest and received CPR within 48 hrs of mechanical ventilation
4) Patients having history of dementia, Psychiatric disorder, on antipsychotic or antidepressants prior to ICU admission
5) Pregnant females and patients having known hypersensitivity to any of the sedative agents
6) Cardiogenic shock, Acute decompensated heart failure, MI
7) Patients having end stage liver failure ( Child Pugh C)
8) Primary neurological injury (TBI, Stroke, SCI, Anoxic brain injury, Brain edema)
9) Hemodynamically unstable patients
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the dose of Propofol required to achieve a target sedation score ( RASS of 0 to -2) when used in combination with Ketamine versus FentanylTimepoint: At Baseline, 24 Hours, 48 Hours after sedation.
- Secondary Outcome Measures
Name Time Method 1) To compare the residual effect on sedation fue to Ketamine versus Fentanyl on stopping the infusion after 72 hours <br/ ><br>2) To compare the anti inflammatory effects of Propofol and Ketamine versus Propofol and Fentanyl by measuring serum TNF alfa and IL 6 levels <br/ ><br>3) To compare the dose of injection Noradrenaline required to achieve MAP more than or equal to 65 mmhg with each combination of sedative agentsTimepoint: 48 hours