Induction and generalization of nocebo effects on itch
- Conditions
- Healthy participants
- Registration Number
- NL-OMON22739
- Lead Sponsor
- eiden University, Leiden, the Netherlands
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Other
- Sex
- Not specified
- Target Recruitment
- 44
1. Healthy participants between 18 and 35 years old;
2. Fluency and regular use of English
1.Refusal to give written informed consent
2.Have received a diagnosis from a doctor of severe physical illness (e.g., multiple sclerosis, heart or lung disease, diabetes, hypothyroidism)
3.Have a psychiatric diagnosis (e.g., depression, autism, ADHD)
4.Are suffering or have suffered from itch lasting for = 6 weeks (e.g., due to allergy or hay fever)
5.Experience itch = 3 on a 0 (not itch at all) to 10 (worst itch imaginable) scale at the start of the testing session
6.Current use of medication
7.Use of drugs (e.g., cannabis, XTC) more than 3 times a month
8.Use of alcohol, any medication or any other form of drugs in the 24 hours prior to participating in the study.
9.Pregnancy or lactation
10.Insensitivity to cowhage, i.e., inability of cowhage spicules to evoke itch (participation will be stopped right after baseline stimuli)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method ocebo effects on cowhage-evoked itch. After receiving the verbal suggestion, the participants will receive two trials with 25 cowhage spicules each, once after application of the ‘itch solution’ and once after application of the ‘control solution’. Our primary outcome is the comparison of the difference in average itch scores between the ‘itch solution’ and the ‘control solution’ trials.
- Secondary Outcome Measures
Name Time Method