Effect of Statins on Sympathetic Activity in Hypertensive Patients with Chronic Kidney Disease: a Randomized trial in Hypertensive Patients with Chronic Kidney Disease

• Conditions: atients older than 18 years old with stable chronic kidney disease and hypertension are included in this project. Patients with diabetes mellitus, patients on renal replacement therapy, patients on antihypertensive medication (which cannot be stopped), patients on immunosuppressive treatment are excluded.

• Registration Number: EUCTR2009-009334-32-NL
• Lead Sponsor: niversity medical center Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2009-02-10
• Last Update Posted: 19 March 2012

Recruitment & Eligibility

• Status: ot Recruiting
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Patients older than 18 years old with stable chronic kidney disease and hypertension are included in this project.
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range

Exclusion Criteria

Patients with diabetes mellitus, patients on renal replacement therapy, patients on antihypertensive medication (which cannot be stopped), patients on immunosuppressive treatment are excluded.

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Secondary Objective: Secondary objectives to study the effect of atorvastatin on kidney function and PRA in hypertensive patients with CKD.;Primary end point(s): muscle sympathetic nerve activity (MSNA);Main Objective: The primary objective is to investigate the effect of a statin (atorvastatin) added to chronic ARB therapy on sympathetic activity in CKD patients. We expect that sympathetic activity will be further reduced.