Effect of intrasocket application of hyaluronic acid on pain, swelling and trismus after surgical extraction of impacted mandibular third molar

Mandibular third molar removal is one of the most widely done treatments in the oral cavity. Nevertheless, surgeons often encounter undesirable post-operative sequalae. These inflammatory responses after wisdom teeth surgery may badly affect a patients’ quality of life.

Post-operative complications like dry socket, nerve damage, bone fracture, delayed healing and damage of the second molar can also happen quite frequently following the surgical removal of mandibular third molars .Though traditional measures such as non steroidal anti-inflammatory drugs and corticosteroids proposed for control of postoperative complications work well ,their potential side effects have led to search for  an easy applicable way  to reduce post-operative pain and swelling.

Hyaluron or hyaluronic acid is a biomaterial that has been introduced as an alternative approach to enhance wound healing. Hyaluronic acid is a major carbohydrate having multifaceted roles. It plays a critical role in wound healing by inducing early granulation tissue formation, inhibiting destructive inflammation and promoting angiogenesis. Owing to its non-immunogenic and non-toxic properties, it has been used in ophthalmology, dermatology, and rheumatology and now has been introduced for intraoral use. It is available in gel or  liquid form to be applied topically in oral cavity.The study aims  to determine the effect of intra socket hyaluronic acid application  on post extraction pain, swelling and trismus after surgical removal of 3rd molar .