The Effect of Increasing the Mean Arterial Pressure on the Microcirculation and the Prognosis of Patients With Septic Shock
- Conditions
- Septic Shock
- Interventions
- Other: vasopressors
- Registration Number
- NCT04136080
- Lead Sponsor
- Fujian Provincial Hospital
- Brief Summary
Background： The mean arterial pressure（ MAP） is a key pressure index to improve tissue perfusion. At present, there are no surprising results of large-scale clinical studies on sublingual microcirculation. The changes of sublingual microcirculation were more severe in septic shock non-survivors than survivors. Purpose： This study is mean to increase the MAP in septic shock patients whether with chronic hypertension or not, so as to observe the change of the microcirculation and prognosis. Method： This is a single-center, randomized, prospective cohort study. Eligible patients will be allocated into chronic hypertension or denying chronic hypertension group. These patients will be treat with vasopressors to maintain MAP at 90±5 mmHg and 70±5 mmHg. Outcome： The 28-day all-cause mortality, the 90-day all-cause mortality, the 28-day without organ dysfunction days, the Changes of sublingual microcirculation, SOFA， APACHE-Ⅱ score Will be recorded.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 752
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description chronic hypertension group vasopressors septic patients with chronic hypertension denying chronic hypertension group vasopressors septic patients without chronic hypertension
- Primary Outcome Measures
Name Time Method the 28-day all-cause mortality and Changes of sublingual microcirculation 28 day the 28-day all-cause mortality and Changes of sublingual microcirculation
- Secondary Outcome Measures
Name Time Method