To study correlation between venous to arterial carbon dioxide difference (Pv-aCO2), PcvCO2-PaCO2/ CaO2-CcvO2ratio and serum lactate during resuscitation in patients with septic shock.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 85
- 试验地点
- 1
- 主要终点
- To evaluate correlation between Pv-aCO2, PcvCO2– PaCO2/CaO2–CcvO2 ratio and the arterial lactate at various time points till 24 hours, in management of patients with septic shock.
研究概览
简要总结
Aim: To study the correlation between venous to arterial carbon dioxide difference (Pv-aCO2), PcvCO2-PaCO2/CaO2-CcvO2 ratio and serum lactate during resuscitation in patients with septic shock.
Objectives:
Primary Objective- To evaluate correlation between Pv-aCO2, PcvCO2–PaCO2/CaO2–CcvO2 ratio and the arterial lactate at various time points till 24 hours, in management of patients with septic shock.
Secondary Objectives-
- To ascertain whether the Pv-aCO2, PcvCO2–PaCO2/CaO2–CcvO2 ratio and the arterial lactate levels in the first 24 hours are able to predict outcome of the patient in terms of: -a.Organ dysfunction at 48 hours, as assessed by Sequential Organ Failure Assessment (SOFA) score (range, 0 [best] to 24 [worst]). b. Vasopressor free days. c. Length of stay in ICU. d. Mortality within 28 days.
- To determine whether the Pv-aCO2, PcvCO2–PaCO2/ CaO2–CcvO2 ratio and arterial lactate are useful in discriminating survivors from non-survivors.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 99.00 Year(s)（—）
- 性别
- All
入选标准
- •PATIENTS ADMITTED WITH SEPTIC SHOCK.
排除标准
- •Patients with all types of Shock other than Septic Shock.
- •Trauma Patients.
- •Pregnant Patients.
- •ARDS, COPD Patients.
- •Seizure Disorder patients.
结局指标
主要结局
To evaluate correlation between Pv-aCO2, PcvCO2– PaCO2/CaO2–CcvO2 ratio and the arterial lactate at various time points till 24 hours, in management of patients with septic shock.
时间窗: To evaluate correlation between Pv-aCO2, PcvCO2– PaCO2/CaO2–CcvO2 ratio and the arterial lactate at various time points 0,6 ,12, 24 hours, in management of patients with septic shock.
次要结局
- 1. To ascertain whether the Pv-aCO2, PcvCO2–PaCO2/CaO2–CcvO2 ratio and the arterial lactate levels in the first 24 hours are able to predict outcome of the patient in terms of: -(a. Organ dysfunction at 48 hours, as assessed by (SOFA) score)
- To determine whether the Pv-aCO2, PcvCO2–PaCO2/ CaO2–CcvO2 ratio and arterial lactate are useful in discriminating survivors from non-survivors.(Survivor from non survivor)