To Understand the relationship between PCO2 gap, calculated respiratory quotient and serum lactate in patients with septic shock.

Not yet recruiting

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2023/10/058869
• Lead Sponsor: DANISH AHMAD

Brief Summary

Aim: To study the correlation between venous to arterial carbon dioxide difference (Pv-aCO2), PcvCO2-PaCO2/CaO2-CcvO2 ratio and serum lactate during resuscitation in patients with septic shock.

Objectives:

Primary Objective- To evaluate correlation between Pv-aCO2, PcvCO2–PaCO2/CaO2–CcvO2 ratio and the arterial lactate at various time points till 24 hours, in management of patients with septic shock.

Secondary Objectives-

1. To ascertain whether the Pv-aCO2, PcvCO2–PaCO2/CaO2–CcvO2 ratio and the arterial lactate levels in the first 24 hours are able to predict outcome of the patient in terms of: -a.Organ dysfunction at 48 hours, as assessed by Sequential Organ Failure Assessment (SOFA) score (range, 0 [best] to 24 [worst]). b. Vasopressor free days. c. Length of stay in ICU. d. Mortality within 28 days.

2. To determine whether the Pv-aCO2, PcvCO2–PaCO2/ CaO2–CcvO2 ratio and arterial lactate are useful in discriminating survivors from non-survivors.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-01-11
• Last Update Posted: 2023-10-13

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 85

Inclusion Criteria

PATIENTS ADMITTED WITH SEPTIC SHOCK.

Exclusion Criteria

• Patients with all types of Shock other than Septic Shock.
• Trauma Patients.
• Pregnant Patients.
• ARDS, COPD Patients.
• Seizure Disorder patients.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To evaluate correlation between Pv-aCO2, PcvCO2– PaCO2/CaO2–CcvO2 ratio and the arterial lactate at various time points till 24 hours, in management of patients with septic shock.	To evaluate correlation between Pv-aCO2, PcvCO2– PaCO2/CaO2–CcvO2 ratio and the arterial lactate at various time points 0,6 ,12, 24 hours, in management of patients with septic shock.

Secondary Outcome Measures

Name	Time	Method
1. To ascertain whether the Pv-aCO2, PcvCO2–PaCO2/CaO2–CcvO2 ratio and the arterial lactate levels in the first 24 hours are able to predict outcome of the patient in terms of: -	a. Organ dysfunction at 48 hours, as assessed by (SOFA) score
To determine whether the Pv-aCO2, PcvCO2–PaCO2/ CaO2–CcvO2 ratio and arterial lactate are useful in discriminating survivors from non-survivors.	Survivor from non survivor

Trial Locations

Locations (1)

MAX SUPER SPECIALITY HOSPITAL; 🇮🇳 Ghaziabad, UTTAR PRADESH, India

MAX SUPER SPECIALITY HOSPITAL

🇮🇳Ghaziabad, UTTAR PRADESH, India

DANISH AHMAD

Principal investigator

7887077978

DANISHHORIZON@ROCKETMAIL.COM