An Open-Label, Non-Controlled Study to Evaluate Outcomes of Pulsed Electromagnetic Field (PEMF) Therapy in Subjects With Various Pain Etiologies
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 180
- 试验地点
- 16
- 主要终点
- Pain Intensity Assessment
研究概览
简要总结
The study is an open-label, non-controlled study of the safety and effectiveness of investigator determined Provant therapy in subjects with pain and/or edema from various pain etiologies. Information collected in the study will be entered into a registry database.
详细描述
This is an open-label, non-controlled trial in subjects with various pain etiologies at multiple centers in the US. Eligible subjects will include those ≥ 22 years of age that have been deemed appropriate for treatment with Provant by the study investigator (prescriber). Subjects will treat based on the treatment prescribed (location, frequency, duration) by the study investigator.
Data from assessments administered as part of standard of practice will be obtained at baseline and, at a minimum, at the end of treatment. If the investigator administers additional assessments during the course of treatment, the data will be collected.
Safety will be assessed during office visits and through review of AE reports and concomitant treatments and medications. All concomitant drug or non-drug treatments used during the study will be recorded.
Information collected in the study will be entered into a registry database.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 22 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subject age is greater than or equal to 22 years.
- •Subject has pain (chronic or acute) and/or edema that the prescriber deems treatment with Provant is warranted.
- •Subject is willing and able to give written informed consent.
- •Female subjects must be post-menopausal, surgically sterile, abstinent, or practicing (or agree to practice) an effective method of birth control if they are sexually active for the duration of the study. (Effective methods of birth control include prescription hormonal contraceptives, intrauterine devices, double-barrier methods, and/or male partner sterilization).
排除标准
- •Subject requires or anticipates the need for surgery of any type during the duration of treatment.
- •Subject has received any investigational drug or device within 30 days or 5 half-lives of the drug, whichever is longer, prior to the Screening Visit or is enrolled in another clinical trial.
- •Subject has used systemic corticosteroids within 2 months of the Screening Visit.
- •Subject has a history of a solid tumor that is not in complete remission for greater than 2 years other than successfully treated non-metastatic basal cell or squamous cell carcinomas of the skin in the treatment area.
- •Subject has a history of blood cancer (e.g., leukemia, lymphoma, multiple myeloma).
- •Subject has a serious psychosocial co-morbidity.
- •Subject has a history of drug or alcohol abuse within one year prior to the Screening Visit.
- •Subject has an implanted pacemaker, defibrillator, neurostimulator, spinal cord stimulator, bone stimulator, cochlear implant, or other implanted device with an implanted metal lead(s).
- •Subject is currently pregnant or planning on becoming pregnant during the treatment period.
- •Subject has been previously treated with the Provant Therapy System.
- •Subject is unwilling or unable to follow study instructions, or comply with the treatment regimen and study visits.
结局指标
主要结局
Pain Intensity Assessment
时间窗: Pain scores collected daily, up to 20 weeks.
Change in Pain from Baseline/Pre-treatment to End of Treatment/Last Available Observation. Pain captured using NPRS, 0-10 scale were 0 = no pain and 10 = worst pain, given to subjects as part of a daily diary.
次要结局
未报告次要终点