CTRI/2009/091/000490已完成4 期
The Impact of Regular Usage of Paracetamol at Therapeutic Doses on Bronchial-Hyper-responsiveness and Lung Functions in the Asthmatic Subjects
il0 个研究点目标入组 30 人开始时间: 待定最近更新:
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 30
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •?Mild- to-moderate asthmatics in accordance with the GINA guidelines
- •? Male and females18?70 years old
- •?Baseline FEV1 ≥60% predicted
- •?PC20 methacholine of ≤8.0 mg/ml
排除标准
- •?Subjects with aspirin induced asthma
- •?Asthmatics with exacerbation of asthma within the previous three months requiring oral steroids, nebulised bronchodilator, antibiotics or an emergency visit to the doctor
- •?Current or past cigarette smoking >10 pack years
- •?History of allergy or sensitivity to paracetamol, aspirin or ibuprofen
- •?Current or past history of liver disease or on potentially hepatotoxic drugs
- •?Deranged liver function, signified by elevated enzyme levels
- •?Current regular use of paracetamol
- •?History of alcoholism, or current excessive alcohol intake
- •?Previous intentional acute overdose of paracetamol, previous suicide attempt or current depression
- •?Evidence of malnutrition or BMI <20 kg/m2
- •?Women of child-bearing age not using adequate contraception
研究者
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