A Multiomics Study Based on the Dynamic Evolution of Endometrial Carcinogenesis
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 300
- 主要终点
- Differences in the expression of these mutant genes among the three groups of participants as assessed by SAS® 9.4
研究概览
简要总结
The goal of this observational study is to draw the characteristic maps of imaging omics, genomics, transcriptome, proteomics, pathological omics, metabolomics, etc. of the dynamic evolution of endometrial carcinogenesis in 100 patients with normal endometrium, 100 patients with atypical endometrial hyperplasia, and 100 patients with endometrial cancer; and then to explore the underlying molecular mechanism, and establish the database system for the dynamic evolution of endometrial carcinogenesis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Pathological diagnosis: normal endometrium, atypical hyperplasia endometrium, or endometrial cancer;
- •Obtain pathological results after undergoing hysteroscopic surgery or hysterectomy;
- •The patient voluntarily participated in this research project with good compliance and was able to complete the enrollment according to the experimental requirements;
- •Sign the informed consent form and consent to the collection and use of their data, and consent to genomics, transcriptome and other tests.
排除标准
- •Patients with malignant tumors in other parts of the body;
- •Suffering from uncontrollable neurological diseases, psychiatric diseases, or psychiatric disorders;
- •Poor compliance and inability to cooperate and describe treatment responders.
结局指标
主要结局
Differences in the expression of these mutant genes among the three groups of participants as assessed by SAS® 9.4
时间窗: January 2026 to June 2026
The mutant genes of participants and their expression as assessed by gene sequencing, RNA sequencing and mass spectrometry analysis
时间窗: August 2023 to June 2026
次要结局
未报告次要终点