The Effect of Radiation Therapy on Tumor Immunity
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Malignant Neoplasm
- Sponsor
- Jonsson Comprehensive Cancer Center
- Enrollment
- 139
- Locations
- 1
- Primary Endpoint
- Outcome measures include changes in tumor-specific immune responses and general immune signature in patients undergoing Radiation Treatment. Reportable endpoints are absolute values of and changes in innate & adaptive immune cells and serum markers.
- Status
- Terminated
- Last Updated
- 3 years ago
Overview
Brief Summary
This research trial studies the effect of radiation therapy on tumor immunity. Standard radiation therapy destroys tumor cells. In response to tumor cell death caused by radiation therapy, the body has an ability to stimulate an anti-tumor response (immunity), but this response is often ineffective in shrinking tumor tissue. Collecting samples of blood from patients before, during, and after radiation therapy to study in the laboratory may help doctors learn more about the effects of radiation therapy on anti-tumor response.
Detailed Description
PRIMARY OBJECTIVES: I. To assess the effect of radiation therapy on tumor immunity. OUTLINE: Samples of blood are collected before, during, and within two weeks after radiation therapy and then stored for analysis of anti-tumor immunity.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Signed and dated Institutional Review Board (IRB)-approved Informed Consent form for the study
- •Received an explanation of the study, including satisfactory answers to all questions related to the proposed research
- •Is undergoing physician directed radiation treatment
Exclusion Criteria
- •The potential Subject is unwilling or hesitant to participate for any reason and/or fails to complete the appropriate Informed Consent form
Outcomes
Primary Outcomes
Outcome measures include changes in tumor-specific immune responses and general immune signature in patients undergoing Radiation Treatment. Reportable endpoints are absolute values of and changes in innate & adaptive immune cells and serum markers.
Time Frame: The time line of interest covers a baseline, pre-treatment sample as well as mid-treatment and a post-treatment, follow-up sample at 3 months.