Association between right heart size in and right ventricular pump function in pulmonary arterial hypertensio

Recruiting

• Conditions: I27.0; Primary pulmonary hypertension

• Registration Number: DRKS00029755
• Lead Sponsor: Thoraxklinik Heidelberg gGmbH

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-08-26
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Invasive diagnosed PAH (mPAP >= 25mmHg, PAWP <= 15 mmHg, PVR >= 3WU)
Patients that receive a change oder dosis escalation in their drug-based therapy for PAH

Exclusion Criteria

Patients younger than 18 years, patient unable to give consent, pregnant patients, relevant comorbidities that speak against the diagnosis PAH

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Correlation between right heart size based on the RA and RV area and the right ventricular pump function (cardiac output)

Secondary Outcome Measures

Name	Time	Method
• Tricuspid annular plane systolic excursion (TAPSE)<br>• Systolic pulmonary arterial pressure (sPAP)<br>• Qualitative RV pump function<br><br>• RAP, RV pressure<br>• systolic, diastolic und medium PAP<br>• PAWP<br>• Cardiac Output (CO), Cardiac Index (CI)<br>• stroke volume<br>• Pulmonal arterial Compliance (PAC)<br>• maximum pulse (measured using a stress catheter or spiroergometry)<br>• PA-oxygen saturation<br>