Neurofeedback Enhanced Cognitive Reappraisal Training

Recruitment & Eligibility

Status: Not yet recruiting

Sex: All

Target Recruitment: 110

Inclusion Criteria

Inclusion Criteria: - Primary diagnosis (primary source of distress and/or interference) of generalized anxiety disorder, social anxiety disorder, panic disorder or illness anxiety disorder based on structured interview. Comorbid phobic disorders allowed, but these cannot be the primary source of interference or distress due to the lowered chances of encountering anxiety-provoking stimuli during the study period - Medically and physically able to consent - Not taking any medication, prescription or non-prescription with psychotropic effects other than birth control or antidepressant (i.e., selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI) with stable dosage for past 4 week - For females, not currently pregnant or actively trying to become pregnant - Ability to tolerate small, enclosed spaces without anxiety - No metals, implants or metallic substances within or on the body that might cause adverse effects to the subject in a strong magnetic field, or interfere with image acquisition (per protocol) - Size compatible with scanner gantry (per protocol) Exclusion Criteria: - Current diagnosis of Obsessive Compulsive Disorder or Posttraumatic Stress Disorder - Current course of individual or group psychotherapy - Current substance abuse or dependence (past 6 months) - Active suicidality with plan or intent - Current psychosis - History of serious neurological illness or current medical condition that could compromise brain function, such as liver failure - History of closed head injury, e.g., loss of consciousness greater (>) approximately (~) 5 minutes, hospitalization, neurological sequela

Exclusion Criteria

Not provided

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in ventrolateral prefrontal cortex (vlPFC) activity (baseline to transfer run) from the reappraise > look contrast.;Change in negative affect ratings of images from the International Affective Picture System (IAPS).

Secondary Outcome Measures