A Research on the Mechanism of Cognitive Bias Modification Training in Internet Gaming Disorders.
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 48
- 试验地点
- 1
- 主要终点
- Resting-state functional connectivity alterations in brain.
研究概览
简要总结
To investigate whether and how the CBM training will alleviate the symptoms of addiction in Internet gaming disorders.
详细描述
The purpose of this study is to use the modification training of cognitive bias to ameliorate the severity and symptoms of Internet gaming disorders(IGD); the neural mechanisms of cognitive bias modification and its effect during cued-induced craving task in subjects with IGD will be investigated as well. This project will be conducted in Beijing, China.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
盲法说明
double blind: both participants and experimenters won't know which group is training group or sham control group.
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •1, DSM-5 recommended diagnosis of Internet gaming disorder :
- •the scores of the 9 items of DSM-5 recommended diagnosis for Internet gaming disorder ≥
- •engagement in popular Internet games (e.g. Arena of Valor, League of Legends and Player Unknown's Battle Grounds) for over 20 hours per week for a minimum of 12 months.
- •2, the scores of the Y-IAT(Young-Internet addiction Test) ≥ 50
排除标准
- •current or history of use of illegal substances and gambling;
- •current or history of psychiatric or neurological illness;
- •current use of psychotropic medications.
结局指标
主要结局
Resting-state functional connectivity alterations in brain.
时间窗: 30-45 minutes after training
Using seed-based and network level functional connectivity analysis, as well as graph theory analysis , functional connectivity in brain under eight minutes resting state will be detected and compared between CBM training group and sham group
task-based fMRI brain activation
时间窗: 45-60 minutes after training
The active of the brain regions in mPFC and VS during AAT task changes after CBM training compared with the sham. There should be an decrease in ventral striatum and amygdala during the cue-induced task. These task-based fMRI data will be contrasted using SPM.
Correlation analysis
时间窗: 30- 60 minutes after training
The correlation between functional network organization in brain across resting state ( task-based fMRI) and cognitive bias scores will be explored.
Behavioral outcome
时间窗: 60- 80 minutes after training
Cognitive bias outside fMRI measured by AAT task takes the response times\[\[Push\_game\_pic-Pull\_game\_pic\]-\[Push\_object\_pic - Pull\_object\_pic\])\] as the index. The response times (cognitive bias scores) will be calculated under Repeated Measurement Anova by using SPSS software.
次要结局
未报告次要终点
研究者
Jin-tao Zhang
Associated Professor
Beijing Normal University