The Repetitive Transcranial Magnetic Stimulation (rTMS) for Amphetamine-type Stimulants Addiction
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Change from Baseline Craving for ATS assessed by Visual Analog Scales (VAS) at 1 month
Study Overview
Brief Summary
The repetitive transcranial magnetic stimulation (rTMS) will be used to treat amphetamine-type stimulant (ATS) addiction.
Detailed Description
The Glutamate and GABA deficits in prefrontal cortex play a vital role in ATS addiction and relapse, and proposed repetitive transcranial magnetic stimulation (rTMS) as a novel interventions. Focused on evaluating Glutamate/GABA functions in prefrontal cortex and functional connectivity with deep brain regions, neuropsychological tests, biochemical tests, magnetic resonance spectroscopy (MRS) and functional MRI will be used to investigate the neurobiological mechanism of ATS addiction and relapse. These methods will also be used to evaluate the efficacy of the novel intervention and investigate the mechanisms. The study will be very helpful to develop novel interventions in clinical practice and decrease ATS-related harm for both the patients and their families.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Single (Participant)
Eligibility Criteria
- Ages
- 18 Years to 50 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •In accordance with the Diagnostic and Statistical Manual of Mental Disorders-5 (DSM-5) for methamphetamine (MA) use disorders
- •Dextromanual
Exclusion Criteria
- •Have a disease that affect cognitive function such as history of head injury, cerebrovascular disease, epilepsy, etc
- •Have cognitive-promoting drugs in the last 6 months
- •Other substance abuse or dependence in recent five years (except nicotine)
- •Mental impairment, Intelligence Quotient (IQ) < 70
- •Mental disorders
- •Physical disease
Arms & Interventions
control group
sham repetitive transcranial magnetic stimulation (rTMS) of the left frontal lobe dorsal lateral effect on ATS dependent induced cognitive dysfunction and other symptoms.
Intervention: sham repetitive transcranial magnetic stimulation (rTMS) (Radiation)
rTMS group
Use randomized, prospective pseudo stimulus controlled clinical trial design, evaluation of repetitive transcranial magnetic stimulation of the left frontal lobe dorsal lateral effect on ATS dependent induced cognitive dysfunction and other symptoms.
Intervention: repetitive transcranial magnetic stimulation (rTMS) (Radiation)
Outcomes
Primary Outcomes
Change from Baseline Craving for ATS assessed by Visual Analog Scales (VAS) at 1 month
Time Frame: Baseline and 1 month
evaluate all participants' craving for ATS by Visual Analog Scales (VAS)
Secondary Outcomes
- Number of participants who relapse(1 month)
- Depression status assessed by Patient Health Questionnaire-9(PHQ-9)(1 month)
- Anxiety status assessed by Generalized Anxiety Disorder Screener (GAD-7)(1 month)
- Cognitive function assessed by Cogstate Battery(1 month)
- Functional connectivity assessed by MRI(1 month)