Eucapnic pH Compared With Arterial pH and Base Deficit

Brief Summary: Neonatal asphyxia per partum can be complicated by severe neurologic sequelae and can lead to neonatal death. Of the 0.2% of live births to cerebral palsy, 10 to 28% would be secondary to neonatal acidosis. Only metabolic acidosis plays a neurotoxic role, explaining the recent interest of Racinet et al. in the development of a new biochemical marker, more specific than pH or base deficit, of neonatal asphyxia per partum at risk of anoxo-ischemic encephalopathy. This eucapnic neonatal pH raises the hope of a biochemical marker of situations at risk of poor prognosis, with high diagnostic value, prognostic and forensic.

Our hypothesis is that eucapnic pH is more efficient than cord blood arterial pH and base deficit in the prediction of adverse neurologic outcomes.

Recruitment & Eligibility

Inclusion Criteria

All birth more than 37 weeks of amenorrhea at the maternity ward of the hospital Femme-Mère-Enfant
from 1st of january 2000 to 31 december 2016

Exclusion Criteria

Infants born out of the hospital and secondarily hospitalized in the hospital Femme-Mère-Enfant
Children with congenital anomalies or without valid arterial and venous umbilical cord samples

Arm && Interventions

Group	Intervention	Description
Hôpital Femme Mère Enfants births	Eucapnic pH	-

Primary Outcome Measures

Name	Time	Method
Number of patients with at least one of these criteria including neonatal seizure, neonatal hypotonia requiring intensive care unit admission, neonatal encephalopathy, and/or neonatal death.	Between 2000 and 2016

Secondary Outcome Measures

Name	Time	Method

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