Observe the effect of drug dexmedetomididne which will be instilled inside trachea, during removal of endotracheal tube after completion of surgery, in middle ear surgeries, a randomised controlled trial.
Not Applicable
- Conditions
- Health Condition 1: H65-H75- Diseases of middle ear and mastoid
- Registration Number
- CTRI/2020/07/026344
- Lead Sponsor
- department of anaesthesia and intensive care
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Patients of age between 18-60 years.
2.American Society of Anaesthesiologists (ASA) physical status I-II.
3.Patients undergoing elective middle ear surgery requiring endotracheal intubation under GA.
Exclusion Criteria
1.Morbid obesity (BMI > 35 kg.m-2).
2.Patients who require rapid sequence induction/ with airway obstruction/ difficult airway
3.Patients with severe cardiovascular, respiratory, hepatic or renal insufficiency.
4.Patients on long-term use of sedative drugs, such as benzodiazepines, barbiturates and other sedative hypnotics.
5.Patient with known allergy to dexmedetomidine.
6.Pregnant women
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1)To compare coughing during recovery from general anaesthesia as a primary outcomeTimepoint: coughing score at 5 min before anaesthesia (T0), immediately after the administration of dexmedetomidine (T1), 5 min after the administration of dexmedetomidine (T2), 10 min after the administration of dexmedetomidine (T3), at the end of surgery (T4), at the point of awareness (T5), at the point of extubation (T6), 2 min after extubation (T7), 5 min after extubation (T8), 15 min after extubation (T9) and 30 min after extubation (T10).
- Secondary Outcome Measures
Name Time Method 2)To compare hemodynamic parameters, sedation and pain as secondary outcomes and complication if anyTimepoint: Hemodynamic parameters such as SBP, DBP, MBP and HR values will be recorded 5 min before anaesthesia (T0), immediately after the administration of dexmedetomidine (T1), 5 min after the administration of dexmedetomidine (T2), 10 min after the administration of dexmedetomidine (T3), at the end of surgery (T4), at the point of awareness (T5), at the point of extubation (T6), 2 min after extubation (T7), 5 min after extubation (T8), 15 min after extubation (T9) and 30 min after extubation (T10).