The Study on the Brain Mechanisms for the Rehabilitation of Working Memory Deficits in Patients With Acquired Brain Injury Using Multimodal Magnetic Resonance Imaging
试验速览
- 阶段
- 2 期
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Training-induced brain activations during working memory tasks in fMRI
研究概览
简要总结
This study aims to conduct a contrast study on the characteristics of functional and structural connectivity of neural networks of working memory in patients with acquired brain injury versus normal controls, using resting-state functional connectivity magnetic resonance imaging, task-specific functional magnetic resonance imaging and diffusion tensor imaging, combined with cognitive behavioral examinations. Another purpose is to reveal the characteristics of dynamic change of neural networks of working memory pre- and post-intervention in patients with working memory dysfunction.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Right handedness
- •Diagnosis of traumatic brain injury or stroke
- •Course of disease within one year
- •The score of MoCA test > 24
- •Able to understand instructions
排除标准
- •Aphasia, unilateral spatial neglect, agnosia, apraxia
- •Hearing impairment or visual impairment
- •History of taking psychiatric drugs
结局指标
主要结局
Training-induced brain activations during working memory tasks in fMRI
时间窗: six weeks
Training-induced increased and decreased brain activations (Number of voxels) during n-back verbal WM task compared to the pre-training baseline
次要结局
- Attention ability assessed by Stroop color-word test(six weeks)
- The fluid intelligence measured by Raven's Standard Progressive Matrices (RSPM) test(six weeks)
研究者
Yun XiaoPing
Director of Department of Rehabilitation Evaluation
China Rehabilitation Research Center