ISRCTN57022672Completed未知
Effect of change in pancreas and liver fat content upon beta cell function and hepatic insulin action during weight loss in type 2 diabetes: a non-randomised interventional treatment trial
ewcastle upon Tyne Hospitals NHS Foundation Trust (UK)0 sites22 target enrollmentStarted: April 23, 2010Last updated:
Trial Snapshot
- Phase
- 未知
- Status
- Completed
- Sponsor
- Enrollment
- 22
Study Overview
Brief Summary
2011 results in https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168743/
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Sex
- All
Inclusion Criteria
- •For type 2 diabetes volunteers:
- •1. Duration of diabetes up to 2 years
- •2. Aged between 25 - 65 years, either sex
- •3. Body mass index (BMI) of 30 - 40 kg/m^2 with stable body weight for preceeding 3 months
- •4. HbA1c between 6.2 and 9.0%
- •5. On treatment with diet alone or diet plus metformin
- •For healthy controls:
- •1. Normal glucose tolerance plasma fasting triglyceride less than 1.8 mmol/l
- •2. No family history of type 2 diabetes
- •3. Matching BMI and age
Exclusion Criteria
- •1. Kidney dysfunction (serum creatinine greater than 150 micromol/l)
- •2. Liver dysfunction (serum alanine aminotransferase [ALT] greater than 2.5 upper limit normal)
- •3. Contraindications to magnetic resonance imaging (MRI) (metal implants and claustrophobia)
- •4. Consumption of greater than 14 units of alcohol per week
- •5. Treatment with sulphonylureas, thiazolidinediones, steroids or beta-blockers
Investigators
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