Effect of change in pancreas and liver fat content upon beta cell function and hepatic insulin action during weight loss in type 2 diabetes
- Conditions
- Topic: Diabetes Research Network, Primary Care Research Network for EnglandSubtopic: Both, Not AssignedDisease: Diabetic Control, Metabolic, ObesityNutritional, Metabolic, EndocrineNon-insulin-dependent diabetes mellitus
- Registration Number
- ISRCTN57022672
- Lead Sponsor
- ewcastle upon Tyne Hospitals NHS Foundation Trust (UK)
- Brief Summary
2011 results in https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168743/
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 22
For type 2 diabetes volunteers:
1. Duration of diabetes up to 2 years
2. Aged between 25 - 65 years, either sex
3. Body mass index (BMI) of 30 - 40 kg/m^2 with stable body weight for preceeding 3 months
4. HbA1c between 6.2 and 9.0%
5. On treatment with diet alone or diet plus metformin
For healthy controls:
1. Normal glucose tolerance plasma fasting triglyceride less than 1.8 mmol/l
2. No family history of type 2 diabetes
3. Matching BMI and age
1. Kidney dysfunction (serum creatinine greater than 150 micromol/l)
2. Liver dysfunction (serum alanine aminotransferase [ALT] greater than 2.5 upper limit normal)
3. Contraindications to magnetic resonance imaging (MRI) (metal implants and claustrophobia)
4. Consumption of greater than 14 units of alcohol per week
5. Treatment with sulphonylureas, thiazolidinediones, steroids or beta-blockers
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <br> 1. Liver fat content<br> 2. Pancreatic fat content<br> 3. Hepatic insulin sensitivity<br> 4. Glucose-induced insulin secretion<br><br> Each of the above is measured at baseline, week 1, week 4 and week 8.<br>
- Secondary Outcome Measures
Name Time Method Glucose control