Lung Ultrasound in Procalcitonin- Guided Antibiotic Discontinuation in Ventilator Associated Pneumonia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 62
- 试验地点
- 1
- 主要终点
- correlation between lung ultrasound and procalcitonin.
研究概览
简要总结
Ventilator Associated pneumonia (VAP) is associated with longer ICU length of stay, prolonged mechanical ventilation, and increased use of antimicrobials, health-care cost and mortality . Acute respiratory infections (ARIs) comprise a large and heterogeneous group of infections, including bacterial infections, viral infections, and infections of other etiologies. Early initiation of adequate antibiotic therapy is the cornerstone in the treatment. However, overuse of antibiotics and prolonged duration of antibiotic therapy in patients with bacterial ARIs in the hospital and intensive care setting is associated with increased resistance for common bacteria, high costs, and adverse drug reactions.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18 years old or greater
- •Ventilator associated pneumonia (VAP) with positive sputum culture.
排除标准
- •pregnancy,
- •use of immunosuppressive agents except for steroids,
- •neutropenia (white blood cell count ≤1000/mL)
- •patients whose primary diagnosis was community acquired pneumonia and other source of infection.
结局指标
主要结局
correlation between lung ultrasound and procalcitonin.
时间窗: 7 days
次要结局
未报告次要终点
研究者
Mona Ammar
Assistant professor
Ain Shams University