The Effect of Vitamin D on in Vitro Fertilization Outcome, a Prospective Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 688
- 试验地点
- 1
- 主要终点
- Ongoing pregnancy rate
研究概览
简要总结
To date, several studies have been done to explore the relationship between Vitamin D level and IVF outcome; however, the results are controversial. Sample sizes in these studies mentioned above were relatively small. In addition, there are no prospective cohort studies in this field. Thus, here the investigators carry this prospective observational cohort study to demonstrate the relationship between vitamin D level and IVF outcome.
详细描述
Vitamin D level is measured before the commence of IVF cycle. According to Vitamin D level, patients are divided into 3 groups: A, Deficient, <20 ng/mL; B, Insufficient, 20-29.9 ng/mL; C, Replete, >30 ng/mL.
Ongoing pregnancy rate are compared among these three groups after controlling age, number of embryos transferred, ect.
In addition, Vitamin D level is also meassured before embryo transfer in FET cycles with PGT treatment. The effect of Vitamin D on IVF outcome is detected in patients transferred with Euploid embryos.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 21 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •age between 21-40 years old
- •basal FSH hormone level less than 10 mIU/mL
- •the first cycle of IVF treatment with standard long protocol
- •both ovarian present and normal uterus.
排除标准
- •Important data missing
- •Gametes donation cycles
- •Anyone that does not meet the inclusion criteria
结局指标
主要结局
Ongoing pregnancy rate
时间窗: 12 weeks after embryo transfer
12 weeks after embryo transfer, gestational sac with fetal heart present inside uterus
次要结局
- Ectopic pregnancy rate(35 days after embryo transfer)
研究者
Yingpu Sun
Director of Reproductive Medicine Center
The First Affiliated Hospital of Zhengzhou University