MedPath

Quality of Life and Patient Needs in Advanced High Grade Gliomas

Completed
Conditions
Quality of Life
Brain Tumor
Anaplastic Astrocytoma
Glioma
Glioblastoma
Registration Number
NCT05039346
Lead Sponsor
Henry Ford Health System
Brief Summary

There is limited knowledge regarding the quality of life and needs of patients with advanced high grade gliomas, especially during the end of life. By doing this research, we are able to assess caregiver and patient symptoms and needs during the end of life phase of patients with brain tumors.

Detailed Description

Purpose: This is a pilot study to prospectively assess the symptoms and quality of life of patients and with advanced high grade glioma and their care takers.

Specific Aims: The aim of this study is to investigate the symptoms of patients with advanced high grade glioma. Patients who failed 3rd line chemotherapy and who require at least occasional assistance will be prospectively followed and their symptoms will be prospectively assessed. Patient's caregiver will be interviewed following the death of the patient to assess clinical symptoms in the last weeks of life and around the time of death.

Methods: Patients will undergo clinical symptom assessment via questionnaire. Patients will be followed by regular semi-structured phone interviews.

Should a patient pass, four weeks following this, the patient's care giver will be interviewed.

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
55
Inclusion Criteria
  • Age >18
  • Tissue proven diagnosis of a high grade brain tumor
  • Disease progression by MRI
  • Therapy resistant tumor to 2nd line chemotherapy
  • Karnofsky Performance Scale (KPS) score of 60 or less
  • Patient will need to assign caregiver
Exclusion Criteria
  • None

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Examination12 months

Clinical assessment

Quality of life and end of life symptoms in brain tumor patients12 months

Assessment will be performed with validated questionnaire (MDASI-BT)

Secondary Outcome Measures
NameTimeMethod

MedPath

Empowering clinical research with data-driven insights and AI-powered tools.

© 2025 MedPath, Inc. All rights reserved.