NCT04938284已完成不适用
The Synergistic Effect of Paired Associative Stimulation and Vagus Nerve Stimulation on Motor-evoked Potential Potentiation in Healthy Subjects
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Motor evoked potential (MEP) potentiation
研究概览
简要总结
Vagus nerve stimulation (VNS) and paired associative stimulation (PAS) have been shown to have efficacy in improving the results of motor rehabilitation after stroke and spinal cord injury, respectively. Here we will investigate in healthy subjects the synergistic effect of these stimulation modalities on motor-evoked potential (MEP) potentiation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •contraindications to TMS (e.g. brain pathology, implanted devices)
- •contraindications to MRI (e.g. MRI incompatible implants)
- •continuous use of CNS-active drugs
- •neurological, psychiatric or cardiovascular disease
- •drug abuse
结局指标
主要结局
Motor evoked potential (MEP) potentiation
时间窗: 90 minutes after the stimulation protocol
MEPs are responses to transcranial magnetic stimulation recorded from target muscles.
次要结局
未报告次要终点
研究者
Anastasia Shulga
Head of Department
Helsinki University Central Hospital
研究点 (1)
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