Combining PAS to Non-invasive VNS

Not Applicable

Completed

• Conditions: Spinal Plasticity
• Interventions: Device: PAS; Device: VNS

• Registration Number: NCT04938284
• Lead Sponsor: Helsinki University Central Hospital

Brief Summary

Vagus nerve stimulation (VNS) and paired associative stimulation (PAS) have been shown to have efficacy in improving the results of motor rehabilitation after stroke and spinal cord injury, respectively. Here we will investigate in healthy subjects the synergistic effect of these stimulation modalities on motor-evoked potential (MEP) potentiation.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-06-11
• Study First Submitted QC: 2021-06-16
• Study First Posted: 2021-06-24
• Study Start: 2021-07-01
• Primary Completion: 2021-12-30
• Study Completion: 2021-12-30
• Status Verified: 2025-05
• Last Update Submitted: 2025-05-12
• Last Update Posted: 2025-05-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

Not provided

Exclusion Criteria

• contraindications to TMS (e.g. brain pathology, implanted devices)
• contraindications to MRI (e.g. MRI incompatible implants)
• continuous use of CNS-active drugs
• neurological, psychiatric or cardiovascular disease
• drug abuse

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
PAS and VNS	VNS	-
PAS and sham VNS	PAS	-
PAS and VNS	PAS	-
PAS	PAS	-
VNS	VNS	-

Primary Outcome Measures

Name	Time	Method
Motor evoked potential (MEP) potentiation	90 minutes after the stimulation protocol	MEPs are responses to transcranial magnetic stimulation recorded from target muscles.

Trial Locations

Locations (1)

Helsinki University Hospital; 🇫🇮 Helsinki, Finland