Intake behavior of nicotine in venous blood in electric cigarettes in the acute phase
- Conditions
- F17.2
- Registration Number
- DRKS00017432
- Lead Sponsor
- Klinik für Psychiatrie und Psychotherapie des Klinikums der Ludwigs-Maximilians Universität München
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 45
Inclusion / exclusion criteria
General inclusion criteria:
• Subjects between 18 and 55 years
• 12-hour abstinence (both e-cigarette users and tobacco smokers)
• CO < 5ppm; Measurement in the expired air using micro-smokerlyzer (Bedfont Scientific Ltd.)
• capacity to consent
Special inclusion criteria for the electric cigarette users
• experienced e-cigarette user for > 3 months, daily consumption
• no consumption of conventional tobacco cigarettes for > 3 months
Special inclusion criteria for smokers
• Smoker for > 5 years daily > 10 cigarettes / day
Exclusion criteria
• Patients under the age of 18 or over 55 years
• acute psychiatric disorders according to ICD-10 / DSM IV
• other serious psychiatric illnesses
• acute suicidality
• existing pregnancy
• Drug, drug or alcohol abuse at the time of the study
• current malignancies in the last 5 years
• severe internal diseases, especially cardiovascular diseases, such as
-- manifest arterial hypertension
-- severe heart disease (DCM, history of a heart attack)
-- pacemaker
-- respiratory failure
• severe active infectious diseases
• CO> 5 ppm in the expirium
• other circumstances that, in the investigator's opinion, militate against patient participation in this study
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Assessment of the speed and concentration of nicotine infiltration of the E-cigarette JUUL compared to the conventional tobacco cigarette in the acute phase at 5 measurement times.
- Secondary Outcome Measures
Name Time Method Assessment of the addictive potential, since drug infiltration and concentration strongly correlate with the addictive potential.