Intervention en Changement Des Habitudes de Vie Par l'Activité Physique et un Support Nutritionnel Durant la Grossesse en Estrie

Université de Sherbrooke1 site in 1 country16 target enrollmentDecember 2011

Overview

The purpose of this study are:

Assess the impact of an intervention to the adoption of healthy lifestyles among pregnant women at high risk of gestational diabetes mellitus on:
- weight gain in pregnancy
- the levels of maternal and fetal adipokines and
- glycemic control maternal and fetal.
Determine whether the adoption of healthy lifestyles in pregnancy is associated with epigenetic changes that influence the levels of adipokines and glucose regulation during pregnancy and in newborns.

Registry

clinicaltrials.gov

Start Date

December 2011

End Date

October 2013

Last Updated

12 years ago

Study Type

Interventional

Study Design

Parallel

Sex

Female

Sponsor

Responsible Party

Principal Investigator

Marie-France Hivert

MD, MSc

Université de Sherbrooke

•be aged ≥ 18 years,
•have a pre-pregnancy BMI ≥ 25 kg/m2,
•be at risk of developing a gestational diabetes mellitus (a history of gestational diabetes mellitus or glucose 1 hour post-50g \> 7.1 mmol/L.

•Pre-pregnancy diabetes detected in the first trimester (A1c \> 6.5%, fasting glucose \> 7.0 mmol/L, random blood glucose\> 11.1 mmol/L, glucose \> 10.3 mmol/L 1 hour post-50g)
•twin pregnancy
•taking medications that can affect blood sugar or weight,
•practice ≥ 150 minutes of physical activity per week
•against formal-indication for physical activity.

Weight change during pregnancy

Time Frame: Weeks 12, 24, 36 of gestation

Levels of maternal and fetal adipokines(Weeks 12, 24 of gestation and at delivery (in cord blood))
Maternal and fetal glycemic control(Weeks 12, 24 of gestation and at delivery)
Determine whether the adoption of healthy lifestyle in pregnancy is associated with epigenetic changes that influence the levels of adipokines and glucose regulation during pregnancy and in newborns.(Weeks 12, 24 of gestation and at delivery (cord blood))
Optimize the intervention before measuring its impact on the prevention of gestational diabetes mellitus on a larger scale.(throughout the study)