Effects of Hydroxychloroquine on Oral Complaints of Sjögren Patients
- Registration Number
- NCT00873496
- Lead Sponsor
- Ege University
- Brief Summary
Chronic inflammation that comprises the exocrine glands' function leads to xerophthalmia and xerostomia in Sjögren's syndrome. The oral consequences range widely and they are related to decreased salivary output. Hydroxychloroquine may inhibit cholinesterase activity in salivary glands via interference with antigen processing mechanism, and thus, the investigators' hypothesis was that salivary gland function may be improved if treated with hydroxychloroquine. The effects of hydroxychloroquine on the salivary flow rate, subjective and objective parameters of the patients were also assessed.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 30
Inclusion Criteria
- Patients who were recently diagnosed with primary SS according to American-European criteria and who were scheduled for HCQ treatment in Ege University Faculty of Medicine, Department of Rheumatology
Exclusion Criteria
- Sjögren patients consuming alcohol or tobacco
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Sjögren Hydroxychloroquine Pre and post treatment establishment of salivary flow rate, objective and subjective clinical oral complications' severity of the patients using hydroxychloroquine
- Primary Outcome Measures
Name Time Method Salivary flow rate, objective and subjective clinical oral complaints 2005 Jan-2009 Jan
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Ege University School of Dentistry
🇹🇷Izmir, Bornova, Turkey