Effects of Hydroxychloroquine on Oral Complaints of Sjögren Patients: a Prospective Sample Study.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Salivary flow rate, objective and subjective clinical oral complaints
研究概览
简要总结
Chronic inflammation that comprises the exocrine glands' function leads to xerophthalmia and xerostomia in Sjögren's syndrome. The oral consequences range widely and they are related to decreased salivary output. Hydroxychloroquine may inhibit cholinesterase activity in salivary glands via interference with antigen processing mechanism, and thus, the investigators' hypothesis was that salivary gland function may be improved if treated with hydroxychloroquine. The effects of hydroxychloroquine on the salivary flow rate, subjective and objective parameters of the patients were also assessed.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Patients who were recently diagnosed with primary SS according to American-European criteria and who were scheduled for HCQ treatment in Ege University Faculty of Medicine, Department of Rheumatology
排除标准
- •Sjögren patients consuming alcohol or tobacco
研究组 & 干预措施
Sjögren
Pre and post treatment establishment of salivary flow rate, objective and subjective clinical oral complications' severity of the patients using hydroxychloroquine
干预措施: Hydroxychloroquine (Drug)
结局指标
主要结局
Salivary flow rate, objective and subjective clinical oral complaints
时间窗: 2005 Jan-2009 Jan
次要结局
未报告次要终点