Referred Pain Areas in Subjects With a Recovered Radius Fracture

Completed

• Conditions: Radius Fractures
• Interventions: Other: Pressure algometry and mapping referred pain areas

• Registration Number: NCT03531801
• Lead Sponsor: Universidad San Jorge

Brief Summary

The purpose of the present study is to investigate pressure algometry and pressure-induced referred pain areas in pain free individuals with a history of distal radius fracture (fully recovered) compared with age and gender matched healthy controls without history of fracture. It is hypothesized that individuals with a recovered radius fracture will have a facilitated referred pain patter towards the wrist but normal pressure pain sensitivity.

Detailed Description

Musculoskeletal injuries, nociception and pain can increase the sensitivity of the central pain mechanisms, which can be extended even after tissue recovery. However, little is known about the status of these central pain mechanisms once subjects are fully recovered from the tissue injury and pain. This information would help to explain pain conditions in which recurrence of the pain episodes is common (e.g low back pain or shoulder pain).

Pressure-pain thresholds have been widely used in pain research to test the sensitivity of the pain system. Additionally, referred pain has been shown as a valid biomarker for the sensitization of the pain system.

The aim of the present study is to investigate pressure pain sensitivity and referred pain patterns of individuals with a history of recovered fracture, compared with healthy controls.

Study Timeline

• Study Start: 2017-10-30
• Study First Submitted: 2018-04-25
• Study First Submitted QC: 2018-05-08
• Study First Posted: 2018-05-22
• Primary Completion: 2018-09-03
• Study Completion: 2018-09-03
• Status Verified: 2018-10
• Last Update Submitted: 2018-10-15
• Last Update Posted: 2018-10-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 44

Inclusion Criteria

• Subjects with a history of distal radius fracture without pain at the moment of the study.

Exclusion Criteria

• Subjects with symptoms (e.g pain), functional limitations, history of other fractures in the upper limb or any other pathology.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Recovered fracture group	Pressure algometry and mapping referred pain areas	The interventions will be conducted on both groups, on two experimental (approximately 45 minutes per session) sessions separated by 24 hours.Pressure algometry consists of measuring pressure pain thresholds at three bilateral muscle sites.Mapping referred pain areas consists of recording on an electronic body chart the area of pain induced by 60s pressure stimulation at 1.2 times the force needed to reach the pressure pain threshold, exerted on the extensor carpi radialis and the infraspinatus muscles.As group-differences can be attenuated at baseline but emerge on a sensitized (exercise-induced soreness) state, these procedures are performed at baseline and 24 hours after evoking exercise-induced muscle soreness. For further clarification see our recent publication PMID:29608510
Control group	Pressure algometry and mapping referred pain areas	This group will receive the same intervention than the recovered fracture group

Primary Outcome Measures

Name	Time	Method
A change in the area of referred rain	24 hours (two experimental sessions separated by 24h).	This outcome measure corresponds to the difference or change in the size and distribution of the pressure-induced referred pain area, between the two experimental sessions.

Secondary Outcome Measures

Name	Time	Method
A change in pressure-pain thresholds	24 hours (two experimental sessions separated by 24h).	This secondary outcome measure corresponds to the force required to produce a MINIMAL pain(1 out of 10 on a 0-10 visual analogue scale)

Trial Locations

Locations (1)

Universidad San Jorge; 🇪🇸 Villanueva de Gállego, Zaragoza, Spain