Detection of Helicobacter Pylori Infection by High Resolution Endoscopy
- Conditions
- Helicobacter-associated Gastritis
- Registration Number
- NCT01434992
- Lead Sponsor
- Kyunghee University Medical Center
- Brief Summary
Although endoscopic findings of H. pylori have been reported in the literature, there is still some debate over whether H. pylori-related gastritis can be diagnosed via endoscopic features alone. Most studies concluded that it is not possible to diagnose H. pylori-related gastritis on the basis of endoscopic findings. However, the resolution power of endoscopy has greatly improved in recent years and the exact examination of gastric mucosa was possible.
- Detailed Description
Our study aimed to achieve the following: (1) describe the H. pylori-related mucosal pattern in the gastric corpus using high-definition endoscopy; (2) evaluate the diagnostic accuracy for H. pylori detection; (3) find the optimal biopsy site for rapid urease test (RUT); (4) validate the inter- and intraobserver agreement in the assessment of endoscopic patterns.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 585
- Patients who underwent upper endoscopy
- Age < 20 or > 70
- Severe systemic disease or advanced chronic liver disease
- Medication history of NSAID, PPI, H2 blockers or antibiotics
- History of H. pylori eradication therapy
- History of gastric surgery
- Recent history of upper GI bleeding
- Gastric or duodenal ulcer (including old scar change) during endoscopy
- Anemia (Hemoglobin level < 10mg/dL)
- Pangastritis
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Diagnosis accuracy for predicting of Helicobacter pylori infection status 1 day
- Secondary Outcome Measures
Name Time Method Assessment of the clinicopathologic factors related to correct diagnosis 7 days
Trial Locations
- Locations (1)
Kyung Hee University Hospital
🇰🇷Seoul, Korea, Republic of