Detection of Helicobacter Pylori Infection by Non-magnifying High Resolution Endoscopy is Possible Within the Gastric Corpus
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 585
- 试验地点
- 1
- 主要终点
- Diagnosis accuracy for predicting of Helicobacter pylori infection status
研究概览
简要总结
Although endoscopic findings of H. pylori have been reported in the literature, there is still some debate over whether H. pylori-related gastritis can be diagnosed via endoscopic features alone. Most studies concluded that it is not possible to diagnose H. pylori-related gastritis on the basis of endoscopic findings. However, the resolution power of endoscopy has greatly improved in recent years and the exact examination of gastric mucosa was possible.
详细描述
Our study aimed to achieve the following: (1) describe the H. pylori-related mucosal pattern in the gastric corpus using high-definition endoscopy; (2) evaluate the diagnostic accuracy for H. pylori detection; (3) find the optimal biopsy site for rapid urease test (RUT); (4) validate the inter- and intraobserver agreement in the assessment of endoscopic patterns.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who underwent upper endoscopy
排除标准
- •Age < 20 or > 70
- •Severe systemic disease or advanced chronic liver disease
- •Medication history of NSAID, PPI, H2 blockers or antibiotics
- •History of H. pylori eradication therapy
- •History of gastric surgery
- •Recent history of upper GI bleeding
- •Gastric or duodenal ulcer (including old scar change) during endoscopy
- •Anemia (Hemoglobin level < 10mg/dL)
- •Pangastritis
结局指标
主要结局
Diagnosis accuracy for predicting of Helicobacter pylori infection status
时间窗: 1 day
次要结局
- Assessment of the clinicopathologic factors related to correct diagnosis(7 days)
研究者
Jun-Hyung Cho
Clinical and research fellow
Kyunghee University Medical Center