Central and Peripheral Circadian Mechanisms Underlying Non-Dipping Blood Pressure in Blacks
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 32
- 试验地点
- 2
- 主要终点
- Core body temperature amplitude
研究概览
简要总结
This study seeks to examine central and peripheral circadian mechanisms in Blacks with appropriately dipping systolic blood pressure (blood pressure that dips by at least 10%) compared with non-dipping systolic blood pressure (blood pressure that dips by less than 10%) using a constant routine protocol. Constant routine protocols are commonly used in the field of circadian biology to examine rhythms in biological processes while controlling the entraining effects of light, activity, and diet.
详细描述
This study will enroll a total of 40 participants (n=20 non-dippers; n=20 dippers) to complete a 30-hour constant routine protocol. Participants will undergo baseline testing that includes anthropometric measurements, clinic blood pressure measurements, completion of self-report questionnaires on sleep and mood, be fitted with an ambulatory blood pressure monitor and actigraphy watch, and be provided with home sleep testing (HST) equipment.
Following completion of baseline assessment, eligible participants will be scheduled for the 30-hour constant routine protocol. The 30-hour constant routine protocol will allow for the hourly collection of saliva, collection of buccal cells every 4 hours, and constant monitoring of core body temperature, all of which are primary outcomes in the assessment of central and peripheral circadian clock markers. Amplitude and phase of these outcomes will be assessed in non-dippers versus dippers.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Black or African American race
- •Age 18 years or older
排除标准
- •Work alternating or night shifts
- •Pregnant or nursing
- •Current illicit drug use
- •History of severe mental illness
- •Medical conditions that would be contraindicated for a constant routine protocol
- •Take anti-hypertensive medications or beta-blockers
- •Severe obstructive sleep apnea
结局指标
主要结局
Core body temperature amplitude
时间窗: Core body temperature amplitude during a 30-hour constant routine protocol
Circadian amplitude of core body temperature recorded and transmitted wirelessly
Melatonin phase
时间窗: Melatonin phase during a 30-hour constant routine protocol
Circadian phase of melatonin obtained from saliva
Melatonin amplitude
时间窗: Melatonin amplitude during a 30-hour constant routine protocol
Circadian amplitude of melatonin obtained from saliva
Core body temperature phase
时间窗: Core body temperature phase during a 30-hour constant routine protocol
Circadian phase of core body temperature recorded and transmitted wirelessly
Buccal cell mRNA expression
时间窗: Expression of Bmal1 and Period 3 during a 30-hour constant routine protocol
Expression of Bmal1 and Period 3 obtained from buccal cell mRNA
次要结局
- Cortisol phase(Cortisol phase during a 30-hour constant routine protocol)
- Cortisol amplitude(Cortisol amplitude during a 30-hour constant routine protocol)
研究者
Stephen Justin Thomas, PhD
Assistant Professor
University of Alabama at Birmingham