Effectiveness of acupuncture for gastrointestinal dysfunction in Parkinson's disease
Not Applicable
- Conditions
- Gastrointestinal dysfunction in patients with Parkinson's diseaseDigestive System
- Registration Number
- ISRCTN14324113
- Lead Sponsor
- Beijing Hospital of Traditional Chinese Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Ongoing
- Sex
- All
- Target Recruitment
- 88
Inclusion Criteria
1. Idiopathic PD diagnosis
2. Gastrointestinal dysfunction meeting Rome IV FGIDs criteria
3. Ability to provide written informed consent
4. Men or women aged 40 to 80 years
5. Liver function, kidney function, blood routine, urine routine, and stool routine are all normal
Exclusion Criteria
1. Gastrointestinal dysfunction caused by other diseases
2. Severe heart, liver, kidney, or other organ dysfunction
3. Have been taking gastrointestinal motility drugs and laxative drugs for a long time
4. Severe cognitive impairment and language impairment who cannot cooperate with the rating
5. Inability to adhere to the study protocol as determined by the investigator
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Gastrointestinal dysfunction is measured using the electrogastrogram at baseline and 4 weeks<br>2. Blood Serum Index is measured using radioimmunoassay at baseline and 4 weeks<br>3. Gastrointestinal dysfunction is measured using the Rome IV functional gastrointestinal disorders (FGID) criteria at baseline and 4 weeks
- Secondary Outcome Measures
Name Time Method 1. Stool analysis by 16S-rRNA high throughput sequencing at baseline and 4 weeks<br>2. The extent of Parkinson's disease is measured using the Unified Parkinson's disease rating scale (UPDRS) and the Hoehn–Yahr Rating Scale at baseline, 4, 12 and 24 weeks