Assessment of the condition of the auditory nerve by diffusion tensor imaging: A pilot study - Diffusion tensor imaging of the auditory nerve

niversitair Medisch Centrum Utrecht0 个研究点目标入组 10 人开始时间: 待定最近更新: 2024年4月23日

适应症

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•In order to be eligible to participate in this study, a subject must meet all of the following criteria:
•- Patients aged 18 or older.
•- Normal function of middle ear (i.e. no acute middle ear infections or tympanic membrane perforations). Air bone gap (reflecting middle-ear function) <10 dB.;Additional inclusion criteria for normal hearing group:
•- Hearing within normal range: hearing threshold for individual frequencies <= 20 dB HL; the average over 0.5,1,2 and 4 kHz <= 15 dB HL;Additional inclusion criteria for SSD group:
•- Hearing in *deaf* ear: hearing threshold for individual frequencies (0.5, 1, 2, 4 kHz) >= 70 dB HL.
•- Hearing in *normal* ear: hearing threshold for individual frequencies (0.5, 1, 2, 4 kHz) <= 30 dB HL. Note that near-normal hearing (not normal but no hearing aid needed) is included by applying a less stringent criterion than for the normal-hearing subjects.

•A potential subject who meets any of the following criteria will be excluded from participation in this study:
•- Abnormal cochlear anatomy in one or both ears (i.e. ossification).
•- Disability which could interfere with the completion of the tests (i.e. psychiatric problems or severe co-morbidity with an expected survival of less than five years).
•- Patients with contraindications for Magnetic Resonance Imaging (MRI)
•- Not fulfilling the criteria of the MRI inclusion list (see file F), including the presence of any type of metal in the body, tattoos on the skin and pregnancy.

发起方

niversitair Medisch Centrum Utrecht