Cancer Pain Single Nucleotide Polymorphisms (SNPs)

Completed

• Conditions: Cancer; Pain

• Registration Number: NCT00956878
• Lead Sponsor: Erasmus Medical Center

Brief Summary

Cancer pain is common in advanced cancer patients. Opioids are the mainstay of treatment in cancer pain. Responsiveness to and tolerability of opioids is, amongst others, determined by small variations in human DNA. Using blood samples from clinically well-defined cancer pain patients, the investigators are going to analyze single nucleotide polymorphisms (SNPs) in genes that are known to be involved in responsiveness to opioids and sensitivity to pain.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-09
• Study First Submitted: 2009-08-10
• Study First Submitted QC: 2009-08-10
• Study First Posted: 2009-08-11
• Primary Completion: 2012-12
• Study Completion: 2012-12
• Status Verified: 2014-12
• Last Update Submitted: 2014-12-23
• Last Update Posted: 2014-12-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 243

Inclusion Criteria

• Cancer pain patients

Exclusion Criteria

• Patients not able to provide informed consent

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
correlation between pain SNPs and equianalgesic opioid requirement	timepoint at blood sample	candidate SNP analysis

Trial Locations

Locations (1)

Erasmus MC, Centrumlocatie en Daniel den Hoed; 🇳🇱 Rotterdam, Zuid-Holland, Netherlands