The Trigger of the First Trial Effect: examing pure Sensory Polyneuropathy Patients

• Conditions: sensory loss in the feet and lower legs; 10034606; Sensory Polyneuropathy; 10012653

• Registration Number: NL-OMON36041
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

Symmetric, sensoric, distal polyneuropathy Diabets Mellitus typ I patients defined as: absence of achillestendon reflex, distal ' sock' gnostic sensoric loss.

Exclusion Criteria

- neurological diseases other than proprioceptic loss in the feet, lower legs and hands
- orthopedic diseases
- vestibular diseases
- severe vision disturbances on 1 or 2 eyes (with glasses): vision below 5/60 = able to count the fingers of the examiner at 5 meters distance
- other diseases with a potentiel abnormal or disadvantageous effect on the equilibrium
- sedic medication
- bloodpressure lowering medication
- pregnancy
- age under 18 years
- Body Mass Index above 25kg/m2

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1. Balance of sensory polyneuropathy in patients compared with that of healthy<br /><br>control subjects (expressed in Center of Mass movement that occurs after the<br /><br>platform tilts). </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Body movements based on 18 different points of limbs, trunk and pelvic tilts<br /><br>of the platform with polyneuropathy in patients compared to healthy controls.<br /><br>- Muscle activity of ten muscles during tilts of the platform measured using<br /><br>surface electromyography.</p><br>